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Antibody Research

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Antibodies Targeting Three Spike Protein Domains Regulating SARS-CoV-2 Infectivity

Infectivity of SARS-CoV-2 is regulated by three sites on the spike protein: a receptor binding motif (RBM), a subunit...

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Generation of Antibodies to Difficult Membrane Protein Targets

Multipass transmembrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal...

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Development of a Defined Cloning and Growth Factor Formulation for Murine Hybridomas

Conditioned media from cultured cells have long been used to increase the cloning efficiency, growth rate and antibody...

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Antibody targeting functional domains of the SARS-CoV-2 Spike protein

Infectivity of SARS-CoV-2 is regulated by three sites on the spike protein: a receptor binding motif (RBM), a subunit...

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Development of human antibodies to human vascular endothelial growth factor -C (VEGF-C) and -D (VEGF-D)

Recent studies have suggested a link between the growth of cysts found in the lungs of patients with...

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Generation Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery

"Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery” details the integration of advanced 3-D...

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Generation of Neutralizing Human Monoclonal Antibodies Against a Therapeutic Target from the Alloy Therapeutics Mouse

Immunization of transgenic animals producing human antibodies is the most successful approach to obtaining fully human...

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A Rapid, High-Throughput Recombinant Antibody Expression System for Therapeutic Antibody Discovery and Validation

Hybridoma cell lines have historically offered an efficient, low-cost means to produce large numbers of monoclonal...

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Generation of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse

Immunization of transgenic animals producing human antibodies is by far the most successful approach to obtaining...

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Therapeutic Antibody Discovery at Antibody Solutions using the OmniAbTM Platform

Antibody Solutions performed its first program in OmniAbTM animals in September of 2012. In our 6.5 year history with...

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Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms

Immunization of transgenic animals producing human antibodies has been the most successful approach to obtaining fully...

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Next-Generation Therapeutic Antibody Discovery from Single B-cells

The most robust strategy for therapeutic antibody discovery continues to be through the use of immunized animals and...

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Generation and Selection of Human Monoclonal Antibodies from the H2L2 Mouse

Human antibody-producing transgenic H2L2TM mice have been used to generate monoclonal antibodies to therapeutic...

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Development of Antibody and PK and ADA Assays for a Cystine Knot Fusion Protein

Cystine knot peptides, also know as knottins, are an emerging class of biotherapeutic molecules that can be engineered...

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Discovery of Therapeutic Antibodies to Difficult Membrane Proteins

Multi-pass trans-membrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal...

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Discovery Platform for Therapeutic D-Proteins

Stereochemistry is a fundamental property of proteins that defines their shape and biologic function. Proteins made of...

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Development of Antibodies and ELISAs to measure Free and Total Obiltoxaximab (ETI-204) in the Presence of Anthrax Protective Antigen PA63

Preclinical and clinical pharmacokinetic (PK) studies require highly specific and high affinity immunoassays to...

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Obtaining Antibodies to Difficult Membrane Targets through DNA and Cell Immunization

Multi-pass transmembrane and multi-meric membrane proteins are targets for the development of therapeutic monoclonal...

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Generation and Selection of Human Monoclonal Antibodies from the OmniRat

Human antibody-producing transgenic OmniRatsTM have been used to generate monoclonal antibodies to therapeutic targets....

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Chemical Synthesis and X-ray Structure of a Heterochiral {D-protein antagonist plus vascular endothelial growth factor} Protein Complex by Racemic Crystallography

Total chemical synthesis was used to prepare the mirror image (D-protein) form of the angiogenic protein vascular...

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Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents

Critical reagents are essential components of ligand binding assays (LBAs) and are utilized throughout the process of...

Cadherin-11 Antagonists and Methods for the Treatment of Inflammatory Joint Disorders

The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The...

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Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor

In this report, we assessed the steady-state enzymatic activity of lysyl oxidase-like 2 (LOXL2) against the substrates...

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DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

Previous studies have shown that blocking DLL4 signaling reduced tumor growth by disrupting productive angiogenesis. We...

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Regulation of BRCA2 Gene Expression by the SLUG Repressor Protein in Human Breast Cells

The expression of the breast cancer susceptibility protein BRCA2 is highly regulated in human breast, ovary, and...

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Therapeutic Targeting of Endothelial Ligands for L-selectin (PNAd) in a Sheep Model of Asthma

The homing of lymphocytes to peripheral lymph nodes is initiated by an adhesive interaction between L-selectin on...

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HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both its Translation and Intracellular Stability

The human immunodeficiency virus type 1 (HIV-1) relies on Vif (viral infectivity factor) to overcome the potent...

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ARMER, Apoptotic Regulator in the Membrane of the Endoplasmic Reticulum, a Novel Inhibitor of Apoptosis

We have identified a novel protein, apoptotic regulator in the membrane of the endoplasmic reticulum (ARMER), which...

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Drosophila p53 is a Structural and Functional Homolog of the Tumor Suppressor p53

The importance of p53 in carcinogenesis stems from its central role in inducing cell cycle arrest or apoptosis in...

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Production of Monoclonal Antibodies Using a Secretion Capture Report Web

We describe a novel method for the production of monoclonal antibodies using a secretion capture report web (SCRW)....

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Laboratory Methods in Immunology - Development of quantitative two-site ELISAs for soluble proteins.

This two-volume reference details immunological techniques for biologists of all disciplines. Volume I includes a...

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Laboratory Methods in Immunology

This two-volume reference details immunological techniques for biologists of all disciplines. Volume I includes a...

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Influence of Adjuvants on the Quantity, Affinity, Isotype and Epitope Specificity of Murine Antibodies

Five adjuvants were compared to Freund's adjuvant for production of mouse polyclonal antibodies and monoclonal...