Antibody Research

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Generation of Antibodies to Difficult Membrane Protein Targets

By Antibody Solutions Research Team on Jan 5, 2021 1:24:00 PM

Multipass transmembrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal antibodies, but they present challenges for antibody generation. Membrane proteins represent ~25% of the entire genome and the majority of those are multi-pass, complex proteins that are challenging to express in a native, bio-active state with appropriate quaternary structure.

Topics: Posters Multi-pass transmembrane Multi-meric Membrane Therapeutic Monoclonal Antibodies Antibody Generation