1 min read
Generation Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery
"Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery” details the integration of advanced 3-D modeling tools for the analysis of proteins and antibody-antigen interactions in our discovery platform. We show that adding molecular 3D modeling to the mix can reduce the cost and time of antibody discovery.
Topics: Transgenic Animals Posters Human Therapeutic Antibodies Immunization
1 min read
Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms
Immunization of transgenic animals producing human antibodies has been the most successful approach to obtaining fully human therapeutic antibodies. They allow for the rapid generation of candidate antibodies to multiple targets of interest and the ability to transition lead candidates to clinical development without undergoing time consuming and costly steps such as humanization or affinity maturation of antibodies from structural display libraries.