FAbs and Other Antibody Fragments
When it’s especially critical to study one portion of the antibody without having to worry about interference from another, antibody fragmentation can quickly become a researcher’s best friend. High-quality, high-performing antigen-binding fragments (Fabs) are prized for their ability to enhance antibody specificity, reduce effector functions and help eliminate needless delays.
Yet finding them on the commercial market can present considerable challenges. Complexities abound: There is variation among species, subclasses of Abs (e.g., IgG1, G2a, G2b, etc.), and even individual antibodies within a subclass (with respect to the enzyme used, rate of digestion, and the incubation period to obtain maximum yields of Fab or F(ab’)2). Further, digestion may affect the antigen binding activity of the antibody.
At Antibody Solutions, we not only understand the intricacies of Fabs, but also have the breadth and depth of knowledge and skills to align our custom-tailored fragmentation services with what’s best for your unique research requirements. For example, we can perform a custom fragmentation with an antibody of your choice. Similarly, some clients have found fragmentation into Fab fragments to offer special value as an immunogen, especially for generating anti-idiotype antibodies. And we’ve generated Fab fragments from whole IgG antibodies to decrease the likelihood of non-specific binding by targeting unique epitopes on the molecule.
In short, we think you’ll find us the ideal one-stop shop for generating the customized Fabs your research project needs--quickly, accurately and cost-efficiently. So the next time you’re looking for an expert (and friendly) hand to support your initiative, just connect with us.