Generation of Antibodies to Difficult Membrane Protein Targets
Joshua K. Lowitz, Glen Lin, Leonel Santibanez-Vargas, Jennifer Somera, Billy Nguyen, and John S. Kenney Antibody Solutions, Sunnyvale, CA, USA
Multipass transmembrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal antibodies, but they present challenges for antibody generation. Membrane proteins represent ~25% of the entire genome and the majority of those are multi-pass, complex proteins that are challenging to express in a native, bio-active state with appropriate quaternary structure.
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