Generation of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse

Joshua Lowitz, Glen Lin, Rick Chang, Jennifer Somera, Leonel Santibanez-Vargas, Julia Teplyuk, Catherine Vo, Emmeline Truong, Billy Nguyen, Gang Deng^, Yiping Rong^, Jiuqiao Zhao^, and John S. Kenney Antibody Solutions, Sunnyvale, CA, USA & ^Harbour BioMed, Newton, MA, USA

Immunization of transgenic animals producing human antibodies is by far the most successful approach to obtaining “fully human” therapeutic antibodies. They allow for the rapid generation of candidate antibodies and the ability to transition lead candidates to clinical development without undergoing time consuming steps such as humanization or affinity maturation of antibodies from structural display libraries. In collaboration with Harbour Biomed and utilizing transgenic Harbour H2L2TM mice, Antibody Solutions has generated therapeutic human monoclonal antibody candidates against an immune checkpoint membrane protein target, designated “HBM-1”.

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