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Molecular Modeling

Predictive Insights Into Your Antibody Discovery

Predicting which antibodies will or will not bind to a specific target is a skill that doesn’t come easy. Although antibodies have the power to bind targets with high affinity and high specificity, understanding the precise atomic interactions that define the “lock-and-key” relationship between an antibody and antigen makes predictive modeling a very tall order.

Molecular modeling has advanced to a point where it is possible to obtain a realistic view of intra- and inter-molecular interactions not available through conventional lab instruments.

Today, 3D molecular modeling can predict the folding of proteins and atomic interactions within a protein or between two proteins, using amino acid sequences alone.

3D molecular modeling image

Generate Value From Molecular Modeling

With our molecular modeling capabilities and expertise, we can literally show you the shape your research should take. The structure of your target antigen can come into sharper focus through in silico modeling of antigen structures and even specific antigen/antibody interactions. These fresh insights have both clinical and financial value: Adding molecular 3D modeling to the mix reduces the time and cost of antibody discovery. Modeling can answer questions quickly, identify promising strategies, and save time and effort at the bench.

Leverage Our Variability in Approach

With a suite of advanced structural modeling services, Antibody Solutions can provide insights into antibody discovery for your project through:

  • Antigen Modeling

    Assess the structure of target domains.

  • Antigen Design

    Guide surrogate antigen synthesis, (i.e. peptides mimicking native protein domains).

  • Antibody Modeling

    Identify CDR shape and solvent exposed residues.

  • Antibody/Antigen Docking

    Identify critical antigen and antibody contact surfaces and residues.

  • Antibody/Antigen Epitope Analysis

    Identify fine specificity of competitive antibodies.

  • Antibody Engineering

    Improve affinity and cross-species antigen binding.

  • Antibody Developability

    Assess sequence liabilities.

In keeping with our unwavering commitment to scientific rigor, modeling can be complemented by our build-and-test services such as antigen expression, analytical assays, protein chemistry, and recombinant antibody expression.

See if Our Research Moves You

You can learn more about the advantages of molecular modeling by downloading this poster: “Generation Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery.” 


Contact Us

The next time you’d like to get a clearer vision of the most efficient path forward for your research, just connect with us and we can explore our molecular modeling platform together.