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Vast Diversity
The complexity and diversity of the natural immune system can be captured through the use of various hosts and immunization strategies.
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Affinity Maturation
The host immune system naturally refines antibodies over time, leading directly to higher affinity and stability.
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High Specificity
Animal-derived antibodies exhibit both high specificity for the target antigen and lower cross-reactivity to self-antigens.
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Enhanced Developability
Antibodies from natural immune systems exhibit more favorable bio-physical properties, which can help close the gap from "candidate" to "product."
Interrogate Whole Populations, Efficiently and Effectively
The more challenging your target, the more critical it becomes to secure a deep, comprehensive set of antigen-specific antibodies. That’s precisely what we deliver your project through our Cellestive platform.
Get More Hits on Target
By pursuing hybridoma, memory B-cell, and plasma B-cell discovery pathways in parallel, we efficiently generate distinct candidate sets, freeing you from the innate limitations or biases present in any one of these pathways. Simply put, with Cellestive, you don’t have to sacrifice any single variable — specificity, diversity, affinity, etc. — in favor of another. Instead, the entire population is open to interrogation, yielding a deep pool of opportunities through streamlined processes that happen in unison, rather than in a back-to-back, serial fashion.
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Screen Thoroughly and Rapidly
With a full immune repertoire at your disposal from any cell secreting an antibody, Cellestive makes merging sequence-based and function-based antibody screening possible. We combine output with paired heavy- and light-chain sequence recovery and rapid high-throughput antibody reexpression, ideally positioning your options efficiently from the broadest sources. In addition, antigen-binding sequences can be reexpressed in multiple formats (bispecifics, Fc-silenced, ADC, etc.) to more fully illuminate how your program can be best situated early in the discovery process.
Stay On-Plan and On-Budget
Delivering an antibody therapeutic to market is getting harder — and more expensive — than ever. So Cellestive is specifically designed to remove antibody generation as a potential pinch point, pain point, or sticking point in your program. “Good science” and “a good spend” aren’t mutually exclusive with Cellestive, since there are no licenses, royalties, or milestone payments required; it’s strictly pay-as-you-go, with built-in pause points. Perhaps more important, you partner with a team that has focused exclusively on fit-for-purpose antibody discovery for 30 years, meaning every lesson learned in that rich history gets applied to your project.
Get More Hits on Target
By pursuing hybridoma, memory B-cell, and plasma B-cell discovery pathways in parallel, we efficiently generate distinct candidate sets, freeing you from the innate limitations or biases present in any one of these pathways. Simply put, with Cellestive, you don’t have to sacrifice any single variable — specificity, diversity, affinity, etc. — in favor of another. Instead, the entire population is open to interrogation, yielding a deep pool of opportunities through streamlined processes that happen in unison, rather than in a back-to-back, serial fashion.
Screen Thoroughly and Rapidly
With a full immune repertoire at your disposal from any cell secreting an antibody, Cellestive makes merging sequence-based and function-based antibody screening possible. We combine output with paired heavy- and light-chain sequence recovery and rapid high-throughput antibody reexpression, ideally positioning your options efficiently from the broadest sources. In addition, antigen-binding sequences can be reexpressed in multiple formats (bispecifics, Fc-silenced, ADC, etc.) to more fully illuminate how your program can be best situated early in the discovery process.
Stay On-Plan and On-Budget
Delivering an antibody therapeutic to market is getting harder — and more expensive — than ever. So Cellestive is specifically designed to remove antibody generation as a potential pinch point, pain point, or sticking point in your program. “Good science” and “a good spend” aren’t mutually exclusive with Cellestive, since there are no licenses, royalties, or milestone payments required; it’s strictly pay-as-you-go, with built-in pause points. Perhaps more important, you partner with a team that has focused exclusively on fit-for-purpose antibody discovery for 30 years, meaning every lesson learned in that rich history gets applied to your project.
