Joshua Lowitz
Recent posts by Joshua Lowitz
6 min read
Functional Assays: Narrowing the Field from Binders to Therapeutic Candidates
Candidate ID: How to go from hits to lead candidates
We tend to think of antibodies as being defined by their specificity and affinity to a particular antigen. Of equal importance, however, are the functional activities of an antibody upon antigen binding. All are valuable to the discovery of therapeutic antibodies, where the goal is to have a drug that can react with a specific disease target and modify its role in the disease. We describe in this post the types of assays and strategies used to identify the most promising therapeutic antibody candidates.
Topics: Antibody Discovery Therapeutic Targets Immunoassays Functional Assays
5 min read
Cell Fusion: A trusted tool that can still be an enigma
“Mystery is at the heart of creativity. That, and surprise.” Julia Cameron
Topics: Insights Hybridoma Cell Fusion
5 min read
Measure Twice, Cut Once: The Value of Target Analysis in Antibody Discovery
Editor’s note: Welcome to 2021, and to our first in a year-long series of posts that will explore the essentials in antibody discovery. We’re starting off with a frequently under-appreciated technique for getting to “yes” or “no” faster — target analysis. Next up, in early February, we’ll be talking about fusions. Thanks for reading, and we invite your ideas on what you consider to be “the essentials” of antibody research success.
Topics: Insights Therapeutic Targets Target Analysis Immunogens
4 min read
Expanding the Repertoire of Antibody Drug Discovery with Lambda Light-Chain Models
Accessing the Untapped Potential of 33% of Human IgG