Recent posts by Joshua Lowitz
6 min read
Candidate ID: How to go from hits to lead candidates
We tend to think of antibodies as being defined by their specificity and affinity to a particular antigen. Of equal importance, however, are the functional activities of an antibody upon antigen binding. All are valuable to the discovery of therapeutic antibodies, where the goal is to have a drug that can react with a specific disease target and modify its role in the disease. We describe in this post the types of assays and strategies used to identify the most promising therapeutic antibody candidates.
5 min read
“Mystery is at the heart of creativity. That, and surprise.” Julia Cameron
Topics: Insights Hybridoma cell fusion
5 min read
Editor’s note: Welcome to 2021, and to our first in a year-long series of posts that will explore the essentials in antibody discovery. We’re starting off with a frequently under-appreciated technique for getting to “yes” or “no” faster — target analysis. Next up, in early February, we’ll be talking about fusions. Thanks for reading, and we invite your ideas on what you consider to be “the essentials” of antibody research success.
4 min read
Accessing the Untapped Potential of 33% of Human IgG