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Antibodies Targeting Three Spike Protein Domains Regulating SARS-CoV-2 Infectivity
Three unique functional domain-specific antibodies to the CoV-2 spike protein. These antibodies can serve as tools to dissect the mechanism of SARS-CoV-2 infectivity and as potential leads for COVID-19 therapeutics.
Influence of Adjuvants on the Quantity, Affinity, Isotype and Epitope Specificity of Murine Antibodies
Five adjuvants were compared to Freund's adjuvant for production of mouse polyclonal antibodies and monoclonal antibodies (McAbs) to human serum albumin (HSA) and interleukin-1 alpha (IL-1 alpha).
Generation and Selection of Human Monoclonal Antibodies from the OmniRat
Human antibody-producing transgenic OmniRatsTM have been used to generate monoclonal antibodies to therapeutic targets.
Generation of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse
Immunization of transgenic animals producing human antibodies is by far the most successful approach to obtaining “fully human” therapeutic antibodies.
Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms
Immunization of transgenic animals producing human antibodies has been the most successful approach to obtaining fully human therapeutic antibodies.
Generation of Antibodies to Difficult Membrane Protein Targets
Multipass transmembrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal antibodies, but they present challenges for antibody generation.
