AS_Hero_Contact

News & Insights

5 min read

The Delta Variant Furin Domain Mutation Favors Greater Infectivity

By Dr. John Kenney on 10/07/2021

The Delta variant has quickly become the predominant strain of SARS-CoV-2. Based on molecular modeling studies, Antibody Solutions was one of the first to propose that the earliest variant, D614G, was more transmissible by promoting furin processing, a key step in virus infection. Consistent with our modeling results, it was later found that a spike protein construct containing the G614 mutation was more susceptible to S1/S2 cleavage by furin. Subsequent SARS-CoV-2 variants have continued to possess the D614G mutation, including the two variants of greatest concern today: Alpha and Delta.

Topics: Covid SARS-CoV-2 Molecuar Modeling Antibody Discovery COVID-19
1 min read

Original Research: Targeting Three Spike Protein Domains Regulating SARS-CoV-2 Infectivity

By Dr. John Kenney on 05/24/2021

Like our research colleagues across the entire global scientific community, our team here at Antibody Solutions continues to further delve into the complexities of SARS-CoV-2 and its mutations in hopes of further illuminating potential paths for additional discovery work. We presented our most recent findings during the 2021 PEGS Boston Virtual Conference & Expo.

Topics: Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19
2 min read

Modeling the Impact of the UK and South African Strain Mutations

By Dr. John Kenney on 02/09/2021

Mutations Found in the South African and UK COVID-19 Virus Strains Improve the Stability of the ACE2-Spike RBD Complex

Topics: Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19
1 min read

Original Research: Generating Antibodies to SARS-CoV-2 Spike Protein Sites

By Dr. John Kenney on 01/19/2021

As we’ve noted in some recent blog posts (here and here, for instance), our team at Antibody Solutions is joining the global scientific community in the collective fight against SARS-CoV-2 and its mutations. That includes both research conducted on behalf of our clients and our own discoveries. 

Topics: News Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19
2 min read

The UK Strain and Other Recent RBD Mutations in the SARS-CoV-2 Virus

By Dr. John Kenney on 12/22/2020

Examining mutations in the SARS-CoV-2 Spike (S) Protein Receptor Binding Domain (RBD) at the ACE2 receptor S protein interface

Topics: News Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19
5 min read

COVID-19 Targets, Tools and Therapeutics (Part 2)

By Dr. John Kenney on 12/15/2020

Antibody Solutions is doing its part to respond to the COVID-19 pandemic, including original research, tool discovery, and participation in in-house and client-sponsored discovery programs. In this new blog series, we examine questions such as: What are the potential targets to treat COVID-19 and its sequelae, and what are the strategies and tools to discover drugs to treat the disease?

Topics: Insights Covid SARS-CoV-2 Molecuar Modeling Transgenic Animals COVID-19
3 min read

COVID-19 Targets, Tools and Therapeutics (Part 1)

By Dr. John Kenney on 10/14/2020

Antibody Solutions is doing its part to respond to the COVID-19 pandemic, including original research, tool discovery, and participation in in-house and client-sponsored discovery programs. In this new blog series, we examine questions such as: What are the potential targets to treat COVID-19 and its sequelae, and what are the strategies and tools to discover drugs to treat the disease?

Topics: Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19
6 min read

News Release: Study Identifies Potential COVID Vaccine & Therapy Research Pathways

By Dr. John Kenney on 06/17/2020

Conformational change of the spike protein furin cleavage domain may enhance virus infectivity

June 16, 2020 (Santa Clara, Calif.) — Research by two U.S.-based antibody discovery companies shows a rise and dominance of a mutant SARS-CoV-2 virus and identifies a new mechanism predicting a competitive advantage of the mutation. The mutation is predicted to induce a structural change in the spike protein of the virus that would enhance virus entry. The study, conducted by Antibody Solutions and Single Cell Technology (SCT), is available on Preprints.org (the study’s findings have not yet been peer-reviewed).

Topics: News Covid SARS-CoV-2 Molecuar Modeling COVID-19
7 min read

Original Research: Joint effort finds advantages conferred by a D614G mutation in the SARS-CoV-2 spike protein

By Dr. John Kenney on 06/05/2020

It’s not often that small biotechnology companies pursue basic research into disease mechanisms. However, the serious impact of the SARS-CoV-2 outbreak on our families, friends, and community has prompted us to seek solutions for solving the COVID-19 pandemic. At Antibody Solutions (AS) and Single Cell Technology (SCT), we sought answers to the nature of the virus infection using our tools at hand.

Topics: Insights Covid SARS-CoV-2 Molecuar Modeling COVID-19