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Plasma B-Cell Discovery with Cellestive

Procuring Plasma B-Cells

Plasma B-cells function like "antibody factories," secreting large quantities of naturally affinity-matured antibodies. They represent the population of B-cells that have evolved the furthest in response to immunization. If you're pursuing the most mature immune response to an antigen, the features of the plasma B-cell pathway through Cellestive may be an ideal fit for your antibody discovery program.

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Broadest Plasma B-Cell Discovery

The simplicity, throughput, and cost effectiveness of our plasma B-cell platform, versus competing platforms, optimizes recovery of everything a plasma B-cell pathway can offer. 

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Broaden Your Starting Options

Our plasma B-cell process allows screening of essentially any cell – from any species – that’s secreting an antibody to your target. This allows you to explore multiple immune cell sources for your project.

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Expand Your Interrogations

We can simultaneously screen antibodies against both soluble antigens and target cells, rank hits, define unique phenotypes, and prioritize the best clones for recovery. This efficiency delivers a refined selection of candidates to move forward to the next steps of your project.

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Achieve Higher Throughputs

We can apply your toughest parameters and phenotypes to a system that can screen 1 million plasma cells in a single workday. This offers the highest throughput for any alternative plasma screening method on the market.

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Pursue Difficult Targets

Our extensive experience generating complex cell-associated antigens, plus the depth of screening provided by our platform, can identify rare native confirmation-dependent antibodies to your target. This enables you to pursue difficult membrane protein targets like GPCRs, ion channels, and more.

Setting You Up for Success 

Longevity. Maturity. Response. All the same advantages that make plasma B-cells an ideal choice are precisely the same that make Antibody Solutions and Cellestive an ideal partner for putting them to work in your next discovery project. 

Getting Started with Plasma B-Cells and Cellestive

Through our plasma B-cell pathway, we can interrogate at least ten times more plasma B-cells in a single run than current alternative methods. It enables the detection of any antibody-secreting cell to both soluble and cell surface antigen. These features allow you to screen larger quantities, faster, thereby freeing you up to pursue promising hits sooner. Combined with our scRNA sequencing and Rapid RecAb expression, we can directly express your hits in a fit-for-purpose format.

But, targeting plasma B-cells is just one of the pathways that may meet your project or target goals. That’s why Antibody Solutions’ Cellestive platform provides a cost- and time-efficient way to navigate multiple pathways, in parallel, with your primary route.

For instance, if your project calls for a larger diversity of hits across a range of affinities, adding our activated B-cell and memory B-cell discovery pathways to your discovery program can deliver a broader set of antibodies.

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Powerful, Practical Plasma B-Cell Discovery Services

If you think your program could benefit from our plasma B-cell discovery services, let’s start a conversation. You bring your goals, challenges, and expectations, and we’ll bring open ears and every advantage Cellestive can provide your team. 

Get Started