Memory B-Cell Discovery with Cellestive
Mobilizing Memory B-Cells
Memory B-cells are the original display platform, and every type of B-cell can offer its own unique value in antibody discovery. Through the expression of antibodies on their surface, memory B-cells can be screened through platforms that enable extremely high throughput and the ability to sort for multiple phenotypes. In addition, they offer a more diverse population of antibodies, with a wider range of properties.

It’s the Original Display Platform
Memory B-cells naturally display antibodies on their surface without the artifacts and mRNA biases inherent in yeast and phage display. Unlike synthetic display platforms, the memory B-cell population has been pre-enriched for antigen binders. This makes our memory B-cell screening pathway more efficient than display alternatives.
It Offers the Greatest Diversity
Memory B-cells have the largest range of antibody affinities and specificities. This diversity allows you freedom to explore antibodies with different characteristics and intended for different formats. It’s an excellent source for cross-reactive antibodies to homologous but different targets.
It Offers Screening Depth
This pathway allows us to screen from tens to hundreds of millions of cells against your target. With this depth, you are more likely to discover the rare events that you are searching for, as well as find a greater number of related clonotypes.
More or Better? With the memory B-cell pathway from Cellestive, the answer is Yes!
Memory B-cells can bring a lot to the table (or, more accurately, to the lab bench). Fully realizing their potential, though, demands a distinct mix of antibody discovery experience and capability, one you’ll conveniently find with a single call to Antibody Solutions.
Put Higher Volumes to Work
We can screen tens or even hundreds of millions of memory B-cells at a time. This makes the memory B-cell pathway the highest throughput pathway of our Cellestive discovery platform.
Put Greater Diversity to Work
Memory B-cell screening provides the greatest recovery of diverse sequence sets — sequences that can be immediately reexpressed and tested in your desired modality.
Put Clearer Efficiencies to Work
Our multiparameter sorting can identify multiple memory B-cell phenotypes and recover them in the primary screen. This means that you can select from an enriched population early on, saving you time and resources.
Put Deeper Expertise to Work
Leveraging decades of experience in flow cytometry sorting, Our memory B-cell pathway allows you to take advantage of a bespoke process and toolset that’s optimized to the distinct needs of your discovery program.
Come for the Memory B-Cell Expertise.
Stay for the Great Customer Experience.
There’s one way to make your memory B-cell program memorable for all the right reasons: Put Cellestive and our team at Antibody Solutions to work on your next antibody discovery project.
Explore Every B-Cell Gateway
Through our memory B-cell pathway, we can interrogate tens or even hundreds of millions of memory B-cells. It enables the detection of the greatest diversity of antibodies to your target. Bespoke reagent generation and multi-parameter allows you to identify rare hits with unique binding properties. Combined with our scRNA sequencing and Rapid RecAb expression, we can directly express your hits in a fit-for-purpose format.
But, targeting memory B-cells is just one of the pathways that may meet your project or target goals. That’s why Antibody Solutions’ Cellestive platform provides a cost- and time-efficient way to navigate multiple pathways, in parallel, with your primary route.

For instance, if your project calls for a larger number of diverse hits across a range of affinities, adding our activated B-cell and plasma B-cell discovery pathways to your discovery program can deliver a broader set of antibodies.
It’s Time to Cut a Fresh Path
If you have a discovery project that demands a large panel of candidates with a wide array of characteristics, Cellestive's memory B-cell pathway offers an ideal approach. Put simply, it’s a go-to for the toughest discovery projects. If that sounds like yours, let’s see how Cellestive can make it all a bit easier.
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