Results for "search term"
Log In
Log In

Activated B-Cell Discovery with Cellestive

Harness Hybridomas to Your Advantage

Activated B-cells immortalized as hybridomas have, time and again, proven their mettle in generating effective antibodies against targets of interest. In short, they have been – and remain – robust, dynamic and dependable sources for antigen-specific antibodies.

Antibody Solutions Activated Hybridoma

Proven Success from a Proven Partner

At Antibody Solutions, we know how to get the most out of hybridomas and we've been doing it for three decades. More importantly, we know how to successfully apply its strengths to your program.

Harness Flexibility

Our exclusive Hybridoma Library™ process offers the flexibility to screen your hybridomas through multiple formats. These include conventional plating, AI-powered xPloration® from OmniAb®, or antigen FACS sorting. Choose one or more formats to suite your discovery project’s unique needs and budget.

Harness Control

Our Hybridoma Library™ process uses proprietary growth and cloning factors to ensure recovery and outgrowth of activated B-cells. Cryopreservation of libraries and clones are offer natural testing and decision points in each program. This way, you’re not locked into potentially unproductive efforts, while giving you the opportunity to revisit your cells’ potential later.

Harness Speed

Put efficiency to work using high-throughput flow cytometry sorting to screen and clone single cells without the need for multiple rounds of sub-cloning. Or use xPloration® to screen hundreds of thousands of antibody-secreting cells in a single run with sequencing. Either way, you get valuable results fast.

Harness Clarity

Our activated B-cell pathways — either FACS sorting or xPloration — ensure antibody monoclonality while cutting down risks of false positives and the need for sub-cloning. They deliver rich, functional data and, almost equally important, they do it early. This allows you to focus on the sequences that are most likely to deliver your desired results.

Joined to a Common Goal: Your Success

Hybridoma capture of activated B-cells uses natural collaboration to win. Appropriately, our team can do exactly the same for your target. Let’s discover together if our activated B-cell pathway is an ideal match for your antibody discovery program.

Capitalize on Antigen Activation

Activated B-cells sit squarely in a useful “sweet spot,” delivering a valuable mix of both relative affinity and diversity among antibody immune repertoires. Our Hybridoma Library approach is time-tested and offers the broadest number of formats for screening. It can be of substantial benefit to discovery projects of any size, regardless of time or budget limitations. Combined with our scRNA sequencing and Rapid RecAb expression, we can directly express your hits in a fit-for-purpose format.

Lab Image 2023_retouched (1)


But, targeting activated B-cells is just one of the pathways that may meet your project or target goals. That’s why Antibody Solutions’ Cellestive platform provides a cost- and time-efficient way to navigate multiple pathways, in parallel, with your primary route. For instance, if your project calls for a larger number of diverse hits across a range of affinities, adding our plasma B-cell and memory B-cell discovery pathways to your discovery program can deliver a broader set of antibodies.

Activated B-Cell Discovery Services with a Bias Toward Action

You may have questions about how to maximize an activated B-cell approach to its full potential. Or you might have already decided that the parallel discovery paths offered by the Cellestive platform are perfect for your project. Either way, we’d love to hear from you and take the next step together.

Get Started