Antibody Research

1 min read

Discovery Platform for Therapeutic D-Proteins

By Antibody Solutions Research Team on Dec 11, 2016 12:55:00 PM

Stereochemistry is a fundamental property of proteins that defines their shape and biologic function. Proteins made of L-amino acids have inherent limitations as drugs since they are degraded by proteases which reduce their halflife and are often neutralized by an immune reaction to the protein. Therapeutic proteins made of D-amino acids overcome these limitations since they are inherently resistant to degradation by proteases and have dramatically reduced immunogenicity. Results for VEGF-A and additional therapeutic target proteins are presented

Topics: Posters Stereochemistry L-amino acids