1 min read
Generation and Selection of Human Monoclonal Antibodies from the H2L2 Mouse
By Antibody Solutions Research Team on Jan 8, 2018 1:33:00 PM
Human antibody-producing transgenic H2L2TM mice have been used to generate monoclonal antibodies to therapeutic targets. Transgenic animals producing human antibodies are by far the most successful approach to obtaining “fully human” therapeutic antibodies. This is largely due to the ability to move transgenic animalderived human antibodies from lead selection directly to clinical development without undergoing lead optimization steps common with humanization of murine Abs or affinity maturation of Abs from phage or other synthetic libraries.
Topics: Posters transgenic H2L2 mice
Filter by Keyword
- Posters (20)
- Publications (14)
- therapeutic monoclonal antibodies (4)
- Multi-pass transmembrane (3)
- Transgenic Animals (3)
- multi-meric membrane (3)
- ELISAs (2)
- Human Therapeutic Antibodies (2)
- Hybridoma (2)
- Monoclonal (2)
- SARS-CoV-2 (2)
- APOBEC3G (1)
- ARMER (1)
- ATX-GX (1)
- Alloy Therapeutics (1)
- Antibody Generation (1)
- BRCA2 (1)
- CEM15 (1)
- Cadherin-11 (1)
- Conditioned Media (1)
- Critical Reagents (1)
- Cystine Knot Peptides (1)
- D Protein (1)
- DLL4 (1)
- Fully Human (1)
- HIV-1 (1)
- HSA (1)
- IL-1 alpha (1)
- Immune B-cells (1)
- Immunization (1)
- Knottins (1)
- L-amino acids (1)
- L-selectin (1)
- LAM (1)
- LBAs (1)
- LOXL2 (1)
- McAbs (1)
- OmniAb (1)
- OmniRat (1)
- PNAd (1)
- Secretion Capture Report Web (1)
- Stereochemistry (1)
- Therapeutic Targets (1)
- Tissue Culture (1)
- VEGF-A (1)
- VEGF-C (1)
- VEGF-D (1)
- antibody discovery (1)
- carcinogenesis (1)
- lymphangioleiomyomatosis (1)
- p53 (1)
- pharmacokinetic (PK) (1)
- transgenic H2L2 mice (1)