A surrogate is a functionally equivalent antibody to the therapeutic antibody candidate while binding specifically to the target ortholog expressed in the intended animal species. Surrogate antibodies are a potential solution to the limited safety testing possible with humanized monoclonal antibodies with restricted species cross-reactivity. For example, anti-cytokine antibody projects often encounter low sequence homology between human and mouse cytokine orthologs. During the process of generating the lead therapeutic candidates, an anti-mouse cytokine antibody can be generated to facilitate the conduct of proof-of-concept studies in rodent efficacy models.
Antibody Solutions offers surrogate antibody discovery and characterization for therapeutic antibody ICH-S6 preclinical safety evaluation.